Volume 4 (2025)
Research Article
Godly Plausible Prismatic Family Gender Balancing Proving a New Game Changer Accomplishing in Short Time Span for Across all 17 UN Sustainable Development Goals
RC Yadav*; Jaya Yadav
In general, people levied every kind of inconveniences to population growth. The United Nations’ 17 Sustainable Development Goals (SDGs) aim to achieve decent lives for all on a healthy planet by 2030. As things stand, most of them are likely to be missed.
Research Article
Anti-Inflammatory and Analgesic Effect of Nutraceutical Formulation in Osteoarticular Diseases
Mauro Sigismondo; Umberto Di Maio; Maria Potenza*
Osteoarthritis (OA) is considered the most common musculoskeletal disease, affecting more than 240 million people worldwide. Most patients develop OA in the lower joints, such as knee or hip. Nearly 30% of individuals over the age of 45 show radiographic evidence of knee (Gonarthrosis) and hip (Coxarthrosis) OA.
Research Article
Effects of Dapagliflozin on Metabolic Parameters and Cardiac Function in Patients with Type 2 Diabetes Mellitus and Coronary Heart Disease
Shuai Yu; Luqiao Wang; Ping Yang*
Seventy-six patients diagnosed with Coronary Heart Disease (CHD) and Type 2 Diabetes Mellitus (T2DM) were included in this study conducted at the Department of Cardiology, First Affiliated Hospital of Kunming Medical University, between January 2022 and August 2023. The patients were stratified ...
Research Article
Cardiac and Renal Damage in Hospitalized Hypertensive Patients: Prevalence, Associated Factors, and Clinical Implications
Bruno Henrique Nunes Mendonça; Valéria Nasser Figueiredo*; Maria Fernanda Siqueira Lancuna; Patrícia Magnabosco; Maria Beatriz Guimarães Raponi; Heitor Moreno Jr; Juan Carlos Yugar-Toledo; Nelson Dinamarco
Hypertension is highly prevalent and constitutes a significant risk factor for Target Organ Damage (TOD), such as cardiac and renal lesions, thereby increasing morbidity and mortality. However, the magnitude of these complications among hospitalized patients remains underexplored in Brazil.
Research Article
Effect of Metal Ions on the Water Vapor Barrier Properties of Spray Coated Cellulose Nanofiber (CNF)- Nano-Montmorillonite (MMT) Composite
Kirubanandan Shanmugam*; Ponnusamy Dhanasekaran; Viswanathan Santhosh
The current study demonstrates how spray coating can be used as a rapid and scalable technique to fabricate CNF-MMT nanocomposites with improved barrier properties, particularly in terms of water vapor permeability.
Review Article
A Review on Novel Coronavirus (COVID-19) Vaccines: AstraZeneca, Pfizer, Moderna
Monish Khan; Kiran Dubey*; Mohd Zaid Chaudhry; Zafar Khan; Shmmon Ahmad
Rapid progress in vaccine development was prompted by the unprecedented global health challenge posed by the emergence of the novel coronavirus disease (COVID-19) caused by SARS-CoV-2. The current state of COVID-19 vaccines.
Research Article
Evaluating the Impact of a New Bilingual Online Career Orientation Tool on Medical Students
Sticca G*; Petruccelli J; Dorion D
Online career orientation tools have become increasingly popular to aid medical students navigate speciality selection during the match process. However, there is a scarcity of publications regarding the impact.
Review Article
Multifactorial Determinants Guiding the Choice of Vitamin B12 Therapy
Emmanuel Andrès, MD, PhD*; Jean-Edouard Terrade, MD; Xavier Jannot, MD; Noel Lorenzo-Villalba, MD
Vitamin B12 (cobalamin) deficiency is a common yet underdiagnosed condition with heterogeneous clinical presentations and diverse etiologies. Its management requires an individualized approach that considers not only the biochemical severity.
Review Article
COVID-19 Study, Drug Selection and Development
Da-Yong Lu*; Ting-Ren Lu
The potential threat of coronavirus outbreak (COVID-19, SARS-CoV-2) maintains worldwide. The therapeutic strategies (drug targeting, selection and combination) to COVID-19 infectious need new biological theory and pharmaceutical insights.
Review Article
Immune Checkpoint Inhibitor–Associated Triple-M Overlap (Myocarditis, Myositis, and Myasthenia Gravis): Epidemiology, Pathophysiology, and the Transformative Role of Artificial Intelligence in Risk Prediction and Management
El Tanani Yahia*
Immune Checkpoint Inhibitors (ICIs) have revolutionized oncology, enabling durable remissions in cancers once deemed incurable. However, this therapeutic success is offset by Immune-Related Adverse Events (irAEs).
Case Report
A Rare Obstetric Case Report of Infertility Diagnosis and Therapeutic Interventions Associated with Non-Communicating Rudimentary Horn Uterus Conception via Transperitoneal Sperm Transmigration
Sakina Sakina*; Pranav Mohandas; Saumya Somani
Mullerian duct anomalies are categorized as a cluster of congenital structural malformations in the development of Müllerian ducts, thus rendering infertility in women. Unicornuate uterus also known as a banana-shaped uterus, is a type of mullerian anomaly wherein only a single mullerian.
Clinical Image
Beyond the Blue: Diagnostic Significance of Reticulocyte Film Coloration
Bashir Abdrhman Bashir*
Reticulocyte labeling, a powerful tool in our quest to understand the biology of erythropoiesis, enables the direct observation of immature erythrocytes by the precipitation of leftover RNA using supravital dyes.
Systematic Review
Taste and Olfactory Dysfunctions on Parkinson's and Alzheimer's Diseases: A Systematic Review
Ioannis Bourakis*; Thomas Tegos; Anastasia Konsta; Marina Makri; and Magdalini Tsolaki
Taste and olfactory dysfunction can be useful tools for the early diagnosis of Alzheimer's (AD) and Parkinson's (PD) diseases. Although they have been described as early symptoms of the aforementioned diseases in the international literature, whether they can be considered precursor biomarkers has not been sufficiently clarified.
Review Article
Nasal Disinfection Managing Upper Respiratory Infection Reveals the Detriment of Autonomic Nervous System Ensuing Neurodegeneration Develops Neuropsychiatric Disorder or Systemic Hypometabolism Responsible for a Variety of Idiopathic Disorders
Yong Tan*
As a representation of Upper Respiratory Infection (URI, herein context refers to viral) COVID occasions us to study relevant subjects. Whereas management draws on lower temperature for breach bio-barrier lining on nasal mucosa to exhibit virucides into epithelia thus a broad-spectrum sterilization
Research Article
Predicting Postoperative Healing in Anal Fistulas: A Nomogram Based on MRI and Clinical Features
Xiu-Xiang Liu*; Hua Ren; Meng Wu
This study sought to explore the clinical characteristics and baseline MRI features of patients with anal fistulas, and to develop and validate a nomogram model using MRI data for predicting postoperative healing outcomes.
Short Commentary
Clinical Images/Videos of Neurodegenerative and Genetic Disorders Combined with Voice-Related Biomarkers
Mette Pedersen*
Camera imaging of patients has been used clinically for some years. Based on studies of voice-related biomarkers in a new book by Springer publishers a combination of video images and voice-related biomarkers is suggested in neurogenerative and genetic disorders.
Research Article
RNA Seq Technique for Identification of Genetic Variants Involved in Breast Cancer
E Ghazizadeh*; Zahra Naseri
Breast cancer is the most common malignancy in women and finding molecular markers to diagnose this cancer in the early stages of development is crucial. Increased expression of genetic variants is a common occurrence in cancers.
Review Article
Carcinogenicity of Radio-Frequency Radiation: Similarities and Differences Between Outcomes of Two Studies
Michael Peleg*; Elliot M Berry; Mora Deitch; Or Nativ; Elihu Richter
We discuss the similarities and the differences between two papers published on the carcinogenicity of radio frequency radiation in the military setting with some overlap of the patients' groups. The first paper reported statistically significant increases of cancer cases while the second did not.
Research Article
Anguish and Strong Sensations of Chest Pain in the Psychiatric Diagnosis
Fernando Filipe Paulos Vieira*
Many depressed and anxious outpatients have reported chest tightness and anguish. The aims of this study is to investigate distinctions between patients with and without anguish in terms of symptomatology and comorbidities and find out whether patients.
Research Article
Healthcare in Georgia: Comparative Analysis and Goals of Sustainability Developmentt
Irine Zarnadze*; Nino Jafaridze; Shalva Zarnadze; Levan Baramidze; Devi Tabidze; Dali Kitovani; Lili Lomtadze; Marina Kajrishvili
The aim of this article is to examine the challenges, which are faced by Georgian Healthcare system regarding fulfilling the Sustainable Development Goals (SDGs) in recent years. It is important to mention, that due to changed world healthcare priorities.
Case Report
Cannabis-Induced Pancreatitis and ST-Elevation Myocardial Infarction: A Case Report
Nino Chagiashvili*; Gia Tomadze; Tamar Chaghiashvili; Ramaz Zosiashvili; Tengiz Maisuradze
Cannabis use has been associated with various short- and long-term health effects, including memory impairment, tachycardia, cognitive decline, and respiratory complications. owever, literature concerning more serious conditions such as myocardial infarction and pancreatitis is still emerging.
Research Article
Comparison of the content of Al, Ba, Ca, Cu, Fe, K, Mg, Mn, Na, Ni, P, S, Si, Sr, Ti and Zn in benignly transformed and normal breast tissue determined by ICP-AES
Vladimir Zaichick*; Denis Dogadkin; Irina Gromyak; Valentina Shirokova; Vladimir Kolotov
Many women around the world suffer from Benign Breast Diseases (BBD). The etiology of this disease remains largely unclear, although it is known that disturbances of somatic elemental homeostasis play a certain role in breast pathology.
Research Article
An update on targeting ferroptosis for generating innovative strategies in treatment of diabetic kidney disease: A narrative review
Kulvinder Kochar Kaur, MD*; Gautam Nand Allahbadia, MD, DNB
Diabetic Kidney Disease (DKD), represents the maximum frequent microvascular complications of Type 2 Diabetes Mellitus (T2DM), that is the greatest etiological factor of End Stage Renal Disease (ESRD).
Case Report
Recurrent Subacute Subdural Hematoma Following Burr Hole Evacuation in a Post-PTCA Patient on Dual Antiplatelet Therapy: Successfully Managed with Middle Meningeal Artery Embolization
Anmol Singh Randhawa*; Swarjith Nimmakayala; Pankaj Gupta; Yogesh Agrawal; Jitendra Singh Verma; Bhawani Shankar Sharma; Rohin Bhatia
Subdural Hematoma (SDH) is a well-recognized complication in patients on antiplatelet therapy, particularly in the elderly or those with prior cardiovascular interventions. We report the case of a 63-year-old male with a recent history of Percutaneous Transluminal Coronary Angioplasty (PTCA) on dual antiplatelet therapy who presented with a subacute SDH.
Case Report
A Rare Case Report of a Giant Epidermoid Cyst
Anmol Singh Randhawa*; Shiteez Agrawal; Bhawani Shankar Sharma; Pankaj Gupta
Epidermoid cysts are usually painless and slowly grow as dome-shaped skin lesions that may have varying textures – from firm to fluctuant. These cysts are commonly found on the neck, trunk, face, scalp, and scrotum.
Research Article
Regular Physical Activity in Large Vessel Vasculitis: Challenges and Therapeutic Potential
Yanbing Zhou; Tianyu Wang; Curry L Koening; Hirofumi Tanaka*
Physical activity is a non-pharmacological and modifiable lifestyle factor that may help reduce cardiovascular risks in large vessel vasculitis by lowering inflammation and enhancing vascular function. However, patients with this condition often encounter substantial barriers to physical activity.
Case Report
Case Report: "Small Round Blue Cells in Pediatric Oncology: A Great Mimicker!
Ankita Sharma; Gurpreet Kaur*; Ankur Ahuja; Somasundaram Venkatesan
Small Round Blue Cell Tumors (SRBCTs) include diverse group of aggressive pediatric malignancies that pose significant diagnostic challenges because of their overlapping histological features. These include Neuroblastoma (NB), rhabdomyosarcoma, non-Hodgkin's lymphoma, Ewing's sarcoma and the closely related Primitive Neuroectodermal Tumour (PNET) and the blastemic component of Wilms' tumour.
Review Article
Understanding the Interrelationship Between Gastroesophageal Reflux Disease (GERD) and Obstructive Sleep Apnea (OSA): A Comprehensive Medical Review
Pardeep Yadav; Atreyi Pramanik; Alka Kumari*
Gastroesophageal Reflux Disease (GERD) and Obstructive Sleep Apnea (OSA) are two prevalent medical conditions with significant global health implications. Emerging evidence suggests a bidirectional relationship between these disorders, with potential shared risk factors and pathophysiological mechanisms.
Review Article
Consumption of Packaged Ultra-Processed Foods Under Emotional Stimuli and Cardiometabolic Risk
Maksym Dmitryan; Zuzanna Jakimowicz; Yiqiao Qin; Joanna Michalina Jurek*
Ultra-Processed Foods (UPFs) consumption has risen dramatically, particularly among individuals prone to emotional eating. This review explores the interplay between emotional eating, UPF consumption, and microplastic exposure, and their consequences on cardiometabolic health.
Research Article
Chronic Kidney Disease of Unknown Etiology (CKDu) in the 21st Century: A Review of Environmental Drivers, Research Advances, and Global Health Challenges
Imesidayo Omua Eboreime-Oikeh, MBBS, FWACP, MSc, PhD*; Oikigbeme Sylvia Oikeh, BA, MD
Chronic Kidney Disease of Unknown Etiology (CKDu) is an emerging epidemic disproportionately affecting agricultural workers in tropical and subtropical regions, with increasing reports from the late 20th to the 21st century.
Review Article
Cancer Related Fatigue
Amel Zemmour*; Sarah Tabouri; Blaha Larbaoui; Ahmed Benbella; Djillali Liabes
Cancer-Related Fatigue (CRF) is a common and underestimated health concern among oncology patients under treatment or cancer survivors, in average 80% of patients experience CRF, it is now accepted as a diagnosis in the international classification of diseases.
Research Article
The Relationship Between Inflammatory Bowel Disease and Valvular Heart Disease: A Retrospective Cross-Sectional Analysis of the National Inpatient Sample (2016-2018)
Elizabeth Rimsky, MD*; Chloe Lahoud, MD; Mark Tawfik, DO; Youssef Jalloul, MD; Jon Javon; Jonathan Spagnola, MD
Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal condition with significant extra-intestinal manifestations, including cardiovascular complications. While the relationship between IBD and atherosclerotic cardiovascular disease is increasingly recognized.
Research Article
Incidence of Breast Cancer in Patient Presented with Breast Pain
Ahmed Tekyeldin*; Wael Ismail
This retrospective cohort study to review the incidence of breast cancer in patients referred with breast pain to the ELM ward breast clinics at King George Hospital, Ilford, between 1st February 2023 and 1st May 2023.
Research Article
Antimicrobial and Antioxidant Activity of Crude Extracts of Medicinal Plants
Dolores Vargas-Álvarez; Guadalupe Mendoza-Sabino; Agustín Damián-Nava; Elvia Rodríguez-Bataz; Sandra Alelí Pineda-Rodríguez; Roxana Reyes-Ríos*
The purpose of this research is to characterize the antibacterial and antioxidant activity of medicinal plant extracts and compare their biological activity with reported plant extracts. The study involved an in vitro evaluation of the antibacterial activity of the extracts against Escherichia coli, Salmonella enteritidis, and Shigella dysenteriae.
Research Article
Acute Pancreatitis in End-Stage Renal Disease: A Nationwide Database Study
Chloe Lahoud*; Toni Habib; Mark Tawfik; Taqi Rizvi; Gennifer Wahbah Makhoul; John Afif; Sherif Andrawes; Suzanne El Sayegh
Acute Pancreatitis (AP) is one of the most common gastrointestinal diseases that require hospitalization. The incidence of AP ranges from 13 to 45 per 100,000 persons in the US. In ESRD, AP poses a challenging diagnosis and requires a tailored therapeutic approach.
Case Report
Subclavian Vein Catheterization Gone Awry: A Rare Case of Subcutaneous Emphysema in a Critically Ill Patient
El Mawla Zeinab*; Balhas Sylvana; Mollaei Chirine; Raad Ali
Subclavian vein catheterization is a common procedure for central venous access in critically ill patients. While generally safe, complications like Subcutaneous Emphysema (SE) and Pneumothorax (PTX) can arise, especially with the supraclavicular approach.
Research Article
Anorectal Lesions in HIV-Infected Patients with Proctological Complaints in Kinshasa
Pauline Phaka Bikuelo*; Hippolyte Situakibanza Nani Tuma; Emmanuel Bomba Di Masuangi; Tony Shindano Akilimani; Murielle Longokolo Mashi; Fiston Mbutiwi Ikwa Ndol; Christian Kisoka Lusungi; Bienvenu Lebuaze Massamba; Jack Kokolomami Hyombo; Charles Mbendi Nlombi; Pierre Muzeke Ayol; Sébastien Mbendi Nsukini; Jacqueline Nkondi Nsenga
Anorectal Lesions (ARL) are common in people living with HIV (PLWH). The aim of this study was to describe the frequency and the clinico-endoscopic and histopathological aspects of ARL in PLWH who presented with proctological complaints.
Research Article
A Study of the Effect of Personalized ERAS Protocol on Perioperative Rehabilitation and Quality of Life in Elderly Patients with Small and Medium-Sized Abdominal Wall Incisional Hernias
Yan Zhou*; Fafu Dou; Yadong Zhou; Zhen Shen; Shengbao Gao
The aim of this study is to evaluate the perioperative effectiveness of a personalized Enhanced Recovery After Surgery (ERAS) program in elderly patients with small and medium-sized abdominal wall incisional hernias.
Short Commentary
In Silico Molecular Docking of Ketoconazole as Topoisomerase I Inhibitors: A Computational Approach
Nishfar K*; Jai Kumar
Using an in-silico technique, the current work sought to find novel drug-like compounds with anticancer characteristics. The human topoisomerase 1-DNA complex (PDB ID 1A35) is selected as the protein.
Research Article
Photoluminescence of Staphylococcus Aureus, Staphylococcus Saprophyticus and Рseudomonas Aerugenosa
Yu А Bandurin*; Sh B Molnar; BM Sharga; О Yu Bandurin; ОO Bandurin
The measurement technique and the results obtained by optical spectroscopy during excitation of bacterial biomass Staphylococcus aureus, Staphylococcus saprophyticus and Рseudomonas aerugenosa by photons described. The photoluminescence spectra of bacterial biomass
Review Article
Isolation of Marine Microalgae for Biodiesel Production
Arti Sharma*; Bhupendra Kumar Verma
Microalgae is one of the best sources of renewable energy production, such as biofuels. The production of biodiesel from microalgae has several advantages, including the high productivity of lipid and the possibility of cultivating them on marginal land. One of the challenges
Case Report
A Pituitary Stalk Interruption Associated with Severe Hypoplasia of The Olfactory Bulb: A Case Report
S Habibi; Y Lammini; Z Essolaymany*; Abourazzak; M Hida
Pituitary stalk interruption syndrome, an uncommon cause of growth hormone deficiency and hypopituitarism, is often revealed during the neonatal period and in childhood. The association with Kallmann syndrome (a rare genetic disease, associating hypogonadotropic hypogonadism
Research Article
The Association Between Health Literacy, Subjective Well-Being, Knowledge About Dietary Supplements and Dietary Supplements Intake in a Sri Lankan University Population
MS Dileeha; DHDWT Amayanthi; TMIUK Tennakoon*
To determine the association between health literacy, subjective well-being, and knowledge about dietary supplements and dietary supplement intake among the staff members at the University of Peradeniya, Sri Lanka.
Case Report
Pulmonary Valve Infective Endocarditis Complicating Patent Ductus Arteriosus: A Case Report and Surgical Management
Alaa Altamimi, MD; Mehdi Belhakim, MD*; Samia Ejjebli, MD; Meryem Amri, MD; Abdenaser Drighil, MD; Rachida Habbal, MD
Patent Ductus Arteriosus (PDA) is a congenital heart defect that, if left untreated, can lead to serious complications, including infective endocarditis. Although infective endocarditis primarily affects the left side of the heart, cases involving the right side, particularly the pulmonary valve, are exceedingly rare.
Research Article
Effect of Early Enteral Nutrition on Clinical Outcome of Acute Pancreatitis: A Meta-Analysis of Randomized Controlled Trials
Ying He, MS, MD; Sitao Tan, MS, MD; Shiran Qin, BS, MD; Xiaoxia Liu, MS, MD; Hongbo Li, MS, MD; Xiaoyu Chen, PhD, MD*
Early nutritional intervention is a crucial consideration in the management of acute pancreatitis, as the presence of nutritional risk can significantly impact the prognosis of the condition. This meta-analysis aims to investigate the effects of early enteral nutrition on patients with acute pancreatitis, assessing both the safety and efficacy of this therapeutic approach.
Research Article
Comparative Efficacy of PRP Combined with Acupoint Injection, PRP Monotherapy, and HA Injection in Knee Osteoarthritis: Evaluation of Short - and Long-Term Outcomes
Hui Zhao#; Jiahao Yang#; Puji Peng; Hongyun Liu; Junhua Wei; Binqiang Chen; Sanhu Wang; Hongjun Zhang*
This study aims to compare the short- and long-term effects of intra-articular Platelet-Rich Plasma (PRP) injections combined with acupoint injections versus PRP injections alone and Hyaluronic Acid (HA) intra-articular injections in the treatment of knee osteoarthritis.