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Latest Articles

Review Article

Rethinking a Routine Pharmacokinetics Paradigm: The Advanced In Silico Models

Oleg Shiryaev; Alexander Bukhvostov; Dmitry Kuznetsov*

Ligand efficiency is a widely used design parameter in drug discovery. The dependence of ligand efficiency on the concentration unit can be eliminated by defining efficiency in terms of sensitivity of affinity to molecular size and this is illustrated with reference to fragment-to-lead optimizations.

Research Article

Burden of Viral and Bacterial Respiratory Infections in Africa: A Systematic Review and Meta-Analysis 2013-2023

Martin Nyahoda*; Annie Kalonda; Katendi Changula; Ngonda Saasa; Edgar Simulundu

Respiratory infections are among the leading causes of morbidity and mortality globally especially in sub-Saharan Africa. The aim of this systematic review and meta-analysis was to compare the prevalence between viral and bacterial respiratory pathogens.

Case Report

A Rare Location of Intramuscular Vascular Malformation: A Case Report

Duaa Knaj*; Ghanem Ahmad; Issa Ahmad

Intramuscular vascular malformations are benign malformations of skeletal muscle vessels. These rare tumors can cause significant symptoms and should be accurate diagnosed. A 25-year-old Syrian woman presented in 2015 with dyspnea and difficulty speaking.

Research Article

Transcateter Aortic Valve Implantation (TAVI) in Patients: Relationship between Renal Resistive Index and Central Aortic Pressure

Şeyda Şahin; Mehdi Karasu*; Yücel Karaca; Örsan Deniz Urgun; İbrahim Halil Kurt

Transcatheter Aortic Valve İmplantation (TAVI) is an alternative to surgical procedure for patients with severe aortic stenosis, which has been applied in recent years. It is widely accepted that the Resistive İndex (RI).

Research Article

Effects of Hematopoietic Oxidative Therapy on Diabetes and Hyperlipidemia When Direct Irradiation of Low-Dose Ultraviolet-C to the Blood

Gi-Beum Kim; Jong-Suk kim*

The study evaluates the effects of Haematogenous Oxidation Therapy (HOT) on the blood when a low dose of Ultraviolet-C (UV-C) is directly irradiated to the blood in diabetes and Hyperlipidemia (HL) rabbit model and to evaluate the effects of treatment on diabetic and HL rabbit.

Research Article

Purification of Aconitine, The Main Ingredient of Aconitum Ciliare Decaisne Using Alkaline Compounds

Jong-Ung Youn; Gi-Beum Kim*

Aconiti tuber is used after its toxicity is reduced by using various processing methods, Suchi (Processing. The processing to use medicine of plants, animals, minerals in Korean and Chinese medicine. It use lots of method like dividing, softening, detoxication.

Research Article

Importance of Factors Affecting Uterine Atony: Analysis Based on Neural Networks

Jun-Yu Pan; Ling Wang*; Kai-Feng Liu; Sheng-Yun Xie

Uterine atony can prolong labor or lead to postpartum hemorrhage, posing a threat to life. Predicting uterine atony prenatally is crucial for choosing delivery methods and formulating emergency strategies.

Case Report

Successful Live Birth in a 42-Year-Old Chinese Female Survivor with Acute Lymphoblastic Leukemia Following Obtained Autologous Viable Embryo at 41-Year-Old via Intracytoplasmic Sperm Injection: A Case Report and Literature Review

Yun-Hui Lai†; Zhe Wang†; Yu-Dong Liu; Shi-ling Chen*

To report a healthy live birth in a 42-year-old advanced age woman who obtained autologous oocyte at 41-year-old via Intracytoplasmic Sperm Injection (ICSI) and formed her own only viable embryo. She developed into Premature Ovarian Insufficiency (POI) after allogeneic Hematopoietic Stem Cell Transplantation (HSCT) following her diagnosis of Acute Lymphoblastic Leukemia (ALL) 23 years ago.

Research Article

Synergistic Anticancer and Antibacterial Effects of Withania somnifera (L.) Dunal Extract-Loaded Chitosan NPs against Staphylococcus Aureus-Associated MCF-7 Breast Cancer Cells

Cletus Anes Ukwubile*; Bem Bartholomew Ijoh; Semen Ibrahim Gangpete

Breast cancer remains one of the most prevalent cancers among women, often co-occurring with bacterial infections such as those caused by Staphylococcus aureus. This co-infection can exacerbate disease progression, complicate treatment, and negatively impact patient outcomes.