It has been reported that dysregulated Transthyretin (TTR) transcript and decreased protein expression during fibrotic progression. Therefore, TTR gene is expected to become a target for hepatic fibrosis monitoring. The study aims to prepare and evaluate a fluorine-18-labeled transthyretin siRNA molecular probe targeting TTR mRNA for PET imaging of liver fibrosis preclinically.

Biliary obstruction arises from various biliary diseases, and its alleviation can minimize obstructive jaundice and reduce risks of acute suppurative obstructive cholangitis. Bio-3D-printed biliary stents, building upon conventional designs, incorporate cells and drug-delivery capabilities to promote biliary repair and lower recurrence rates.

In general, people levied every kind of inconveniences to population growth. The United Nations’ 17 Sustainable Development Goals (SDGs) aim to achieve decent lives for all on a healthy planet by 2030. As things stand, most of them are likely to be missed.

Osteoarthritis (OA) is considered the most common musculoskeletal disease, affecting more than 240 million people worldwide. Most patients develop OA in the lower joints, such as knee or hip. Nearly 30% of individuals over the age of 45 show radiographic evidence of knee (Gonarthrosis) and hip (Coxarthrosis) OA.

Seventy-six patients diagnosed with Coronary Heart Disease (CHD) and Type 2 Diabetes Mellitus (T2DM) were included in this study conducted at the Department of Cardiology, First Affiliated Hospital of Kunming Medical University, between January 2022 and August 2023. The patients were stratified ...